细菌生物膜的形成及耐药机制研究进展
Progress on Bacterial Biofilm Formation and Antibiotics Resistance Mechanisms

作者: 周 敏 , 尤理想 , 赵 青 , 李嫄渊 , 吴淑燕 , 黄 瑞 :苏州大学基础医学与生物科学学院病原生物学系,苏州;

关键词: 细菌生物膜耐药性耐药基因质粒Bacterial Biofilm Antibiotic Resistance Drug Resistance Genes Plasmid

摘要:
细菌对抗生素的耐药性已成为全球关注的医学及社会问题,细菌生物被膜(Bacterial biofilm, BBF)是细菌耐药性产生的一个重要方面。BBF是由细菌及其产生的胞外大分子多聚物形成的一种特殊细菌群落。这种细菌群落具有特殊的空间结构,能产生很强的屏障作用,抵抗抗生素的杀菌作用,并且可以加强群落内细菌的交流,传递耐药基因。在耐药基因的传递过程中,质粒作为基因的载体起到了极大的作用。同时,BBF与基因表达存在相互影响的关系。对BBF、耐药基因及质粒的研究,可以提高对BBF耐药性播散的认识,有助于防治细菌耐药性。
Bacterial resistance to antibiotics has become a global medical and social issue. Bacterial biofilm (BBF) is an important aspect of bacterial resistance. It is a special bacterial community formed by bacteria and their extracellular polymeric matrix. It has a special spatial structure that can produce a strong barrier to resist antibiotics, enhance the communication among bacteria and transfer the resistance genes. In the process of the transmission of resistance genes, plasmid plays a great role as gene vector. Meanwhile, BBF interacts closely with gene expression. The research on BBF, plasmid and drug resistance genes can facilitate understanding of the spread and prevention of BBF resistance.

文章引用: 周 敏 , 尤理想 , 赵 青 , 李嫄渊 , 吴淑燕 , 黄 瑞 (2013) 细菌生物膜的形成及耐药机制研究进展。 微生物前沿, 2, 98-101. doi: 10.12677/AMB.2013.24018

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