Predicting Molecule Pathways between LOXL1 and TGF-β

作者: 龚晓楠 , 施丽冰 , 邹晓晖 :浙江大学生命科学学院,杭州;浙江大学医学院,杭州;

关键词: LOXL1TGF-β数据挖掘网络LOXL1 TGF-β Data Mining Network


POP refers to a pelvic floor structure support disorder that visceras in the female pelvic cavity move down along its normal position. However, there is no radical cure for it. So it is a significant research to inquire the pathogenesis of POP. From the information already in hand, we know that LOXL1 knock-down mouse will always produce POP after delivery. In the meantime, the expression of TGF-β has a strong relationship with the severity of POP. On the basis of the data already known, we search for the massive data on the Internet and chose two data sets to do the analysis. As for data mining, we do correlation analysis and cluster on the microarrays that we had chosen. Finally, to show it more clearly, we set up a biology network. We found that TGF-β can regulate the expression of LOXL1 through the smad and non-smad pathways, meanwhile, LOXL1 is involved in the formation of focal adhesion and the crosslinking between elastin and collagen.

文章引用: 龚晓楠 , 施丽冰 , 邹晓晖 (2013) LOXL1与TGF-β相关分子作用路径的预测。 临床个性化医学, 1, 1-6. doi: 10.12677/jcpm.2013.11001


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