Denosumab, a RANKL Inhibitor, Induced Osteonecrosis of the Jaw
Abstract: The two main kinds of drugs that induced osteonecrosis of the jaw are bisphosphonates and anti-RANKL. Anti-RANKL is a fully human monoclonal antibody. It is effective to prevent skeletal-related complications in cancer patients with bone metastasis and to increase bone mineral density in patients with osteoporosis. This article summa- rizes the mechanism of action, clinical use, adverse effects of denosumab and its comparison with bisphosphonates as well as osteonecrosis of the jaw induced by it.
文章引用: 胡龙威 , 徐立群 (2014) RANKL抑制剂地诺塞麦所致颌骨坏死。 外科， 3， 1-5. doi: 10.12677/HJS.2013.31001
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