Objective: To summarize the positive mechanical ventilation in the emergency department treatment of critically ill patients experience applied to improve the overall level of aid. Methods: 76 cases in our hospital emergency rescue of critically ill patients through mechanical ventilation are retrospectively analyzed. Results: In 76 cases of patients undergoing emergency mechanical ventilation, 63 cases are of one-time successful intubation, and the success rate was 82.9%; 13 cases are secondary success, and mechanical ventilation, intubation time < 5 min. 5 cases were given trachea cannula, and after successfully establishing artificial ventilation and mechanical ventilation, all survived with further rescue; 11 cases of severe head injury patients underwent mechanical ventilation, and then they were safe to transport to specialist treatment, and 2 patients died of cerebral hernia. 42 cases of sudden death in patients with mechanical ventilation included: 10 cases failed to restore effective circulating, 2 cases of drowning, 6 patients with unexplained respiratory cardiac arrest after mechanical ventilation, 6 cases of chronic obstructive pulmonary disease, and 4 cases of acute failure of left heart sent to the ICU after mechanical ventilation for continuing rescue. Conclusion: Mechanical ventilation is one of the crucial steps in critically ill patients’ emergency rescue, and it plays an important role in ensuring further cardiopulmonary resuscitation and improving the survival rate of critically ill patients.