盐酸文拉法辛的合成
Synthesis of Venlafaxine Hydrochloride

作者: 朱园园 * , 古双喜 :武汉工程大学化工与制药学院,绿色化工过程教育部重点实验室; 李婷婷 :中国科学院武汉水生生物研究所;

关键词: 盐酸文拉法辛合成抗抑郁药茴香醇Venlafaxine Hydrochloride Synthesis Antidepressant Anisic Alcohol

摘要:

以廉价易得的茴香醇为原料,经7步反应以56.7%的总收率合成得到盐酸文拉法辛。该路线简捷高效,反应条件温和,后处理操作简单,适合工业化生产。 

Venlafaxine hydrochloride was synthesized via 7-step reactions in the total yield of 56.7% from anisic alcohol. The synthetic route is concise and efficient, and suitable for industrialization due to its mild reaction conditions and simple post-treatment.

 

文章引用: 朱园园 , 李婷婷 , 古双喜 (2013) 盐酸文拉法辛的合成。 合成化学研究, 1, 1-3. doi: 10.12677/SSC.2013.11001

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