Objective: To study the clinical curative effect of the midazolam pump into vein for treating children with status epilepticus, and discuss the curative effect of the positive medical intervention to control adverse reactions such as infection, disturbance of consciousness and respiratory depression. Methods: 90 cases of status epilepticus (SE) children, who were admitted between December 2011-October 2012 as observation objects, were randomly divided into two groups: treatment group (46 cases) was given midazolam continuous intravenous pumping, and the 46 cases were randomly divided into two groups: each group composed of 23 cases, one group being given positive medical intervention, and the other group being given regular medical care; control group that has 44 cases, which were only given the traditional first-line antiepileptic drugs (AEDs) treatment, and they were randomly divided into two groups: each group composed of 22 cases, one group being given positive medical intervention, and the other group being given regular medical care. Finally, the curative effect between the two groups and the two different medical interventions in the probability of the occurrence of adverse reactions were compared. At last, comparing between groups, we made good use of the statistical soft ware to deal with the data. Result: The response rate of the efficient treatment group was obviously higher than that of the control group (P < 0.05), the treatment group of midazolam is safe and effective dosage is 0.1 to 0.5 mg/(kg·h), the positive incidence of adverse reactions (15.2%) of the medical intervention group was obviously lower than that of the control group patients (P < 0.05). Conclusions: The continuous intravenous drip of midazolam is a safe and effective control of the treatment of children with status epilepticus, and positive health care intervention can significantly reduce the incidence of infection, and adverse reactions such as disturbance of consciousness, and can be popularized.