Research of Change of Serum Concentration of Cytokines TGF-β and VEGF in Post-Burned Hypertrophic Scar Patients
Abstract: Objective: To explore the dose and its clinic significance of profibrotic cytokines of TGF-β and VEGF in the serum of hypertrophic scar patients at excessive stages. Methods: Serum samples of 74 inpatients were collected, who were admitted to our hospital between 2009, 8 and 2011, 8 and were suffering from post-burned hypertrophic scars at various stages. Serum samples of 12 cases of healthy persons were also collected as the control group. Hypertrophic scar groups were divided into 4 subgroups according to the phase of scars and detected the concentrations of TGF-β and VEGF in serum of the trials using the ELISA method. Results: The doses of TGF-β and VEGF began to increase in 1 to 3 months hypertrophic scar group and achieved summit concentration in 4 to 6 months scar group. The concentration of TGF-β and VEGF degreased gradually with the maturation of hypertrophic scars. Conclusions: High concentration of TGF-β and VEGF in the serum can reflect the level of metabolic activity in the tissue of hypertrophic scars. TGF-β and VEGF may be a promising marker in discerning the growth and development of hypertrophic scars.
文章引用: 沈 锐 , 张金明 , 张凤刚 , 杜永军 , 宋红梅 , 陈晓东 , 徐路生 (2013) 烧伤后增生性瘢痕患者血清中TGF-β、VEGF的浓度检测及意义。 外科， 2， 23-26. doi: 10.12677/HJS.2012.24006
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