丝素溶液的瞬时凝胶化
Instantaneous Gelatination of Silk Fibroin Solution

作者: 沈旖云 :现代丝绸国家工程实验室,苏州大学,苏州;医学部药学院,苏州大学,苏州; 孙姗 , 张芳 , 卢神州 :现代丝绸国家工程实验室,苏州大学,苏州;

关键词: 丝素蛋白瞬时凝胶化水凝胶结构Silk Fibroin Instantly Gelation Hydrogel Structure

摘要:
蛋白质溶液具有凝胶化趋势,其中丝素蛋白的凝胶化在常温下需要十几天的时间。本文提出了一种促使丝素蛋白瞬时凝胶化的方法,该方法能够促使丝素蛋白水凝胶瞬时形成。SEM分析显示该水凝胶内部为疏松多孔的三维交联网状无规则卷曲结构,且有很多微球状的结构交联在一起。利用X衍射、红外光谱等手段进行检测,结果显示丝素蛋白分子快速凝胶化过程中,其分子结构基本保持无规卷曲不变。该瞬时凝胶化的丝素水凝胶具有一定的力学性能和保水性能,可以用于化妆品以及组织工程材料。
>Protein solution has a tendency of gelation. For silk fibroin solution, it needs more than ten days to gel at room temperature. This paper proposes an efficient method to promote instant silk fibroin gelatinization. SEM analysis showed that the instantaneous silk hydrogel had a porous three-dimensional network structure with random curves crossed inside. Besides, there are a lot of micro globular structures cross-boned together. The results from X-ray Dif- fraction (XRD) and Fourier Transform Infrared spectrum (FTIR) showed that the molecular structure of silk fibroin has little change and maintains random coils during the rapid gelation process. This kind of instantaneous hydrogel has ex- cellent mechanical properties and moisture retention performance, so it can be used for moisturizing cosmetics and tis- sue engineering material.

文章引用: 沈旖云 , 孙姗 , 张芳 , 卢神州 (2013) 丝素溶液的瞬时凝胶化。 材料科学, 3, 187-191. doi: 10.12677/MS.2013.35034

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