丙泊酚的非麻醉作用的研究进展
Advances in Studies on the Non-Anaesthetic Effects of Propofol

作者: 萧朱 , 朱伟 :广东医学院分子诊断重点实验室分子病理平台,东莞; 武蕾洁 , 龙军 :中山大学中山医学院,广州; 陈志红 , 罗辉 :广东医学院药学院药理教研室,湛江;

关键词: 丙泊酚非麻醉效应综述Propofol Nonanaesthetic Effects Review

摘要:
丙泊酚做为一种短效的静脉麻醉剂不仅是在手术室,而且也在其他科室得到广泛的应用。除了它的具有的多种麻醉优点外,近来的研究发现丙泊酚也有一些非麻醉的效应。丙泊酚参与了NOS/NO通路;具有抗焦虑的特性;同时,它具有抗氧化、免疫调节、止痛、止吐和神经保护作用。丙泊酚的这些非麻醉的特性可能扩大丙泊酚的临床应用。
Propofol is a short-acting intravenous anaesthetic agent which has gained wide acceptance not only in oper-ating rooms but also in other departments, due to its several advantages. Apart from its multiple anaesthetic advantages, it has been reported recently that propofol exerts a number of nonanaesthetic effects. Propofol is involved in NOS/NO pathway and has anxiolytic properties. Moreover, it has antioxidant, immunomodulatory, analgesic, antiemetic and neuroprotective effects. All these nonanaesthetic properties may expand the clinical use of propofol.

文章引用: 萧朱 , 武蕾洁 , 陈志红 , 龙军 , 朱伟 , 罗辉 (2013) 丙泊酚的非麻醉作用的研究进展。 生理学研究, 1, 7-10. doi: 10.12677/JPS.2013.12002

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