The Research on Pain Mechanism Based on the Spectrum Analysis of EEG
Abstract: Pain is one of the most important sensations in daily life. It is necessary to get the essence and mechanism of pain in pain treatment and control. In this article, the pain was induced through injection angelica on the left shoulder of 12 cases volunteers, and as placebo-control stimulation, the isotonic saline was injection. And through the spectrum analysis of EEG signals, the power percentiles of δ, θ, α, β were extracted during the experiment to study on the modu- lation effect of pain to brain information and central mechanism. The research demonstrated that the δ band energy ratio increased and the θ, α, β band energy ratio decreased after pain stimulation, though the activated areas were not strictly same, they mainly located on left frontal cortex, left temporal cortex, left parietal cortex, occipital cortex. It indicated that these areas were modulated significantly by pain stimulation.
文章引用: 童基均 , 亢艳芹 , 张光磊 , 刘进 , 蔡强 (2013) 基于脑电信号频谱分析的疼痛机理研究。 生物物理学， 1， 25-31. doi: 10.12677/BIPHY.2013.12004
 A. C. N. Chen. New perspectives in EEG-MEG brain mapping and PET-fMRI neuroimaging of human pain. International Jour- nal of Psychophysiology, 2001, 42(2): 147-159.
 A. C. N. Chen. Human brain measures of clinical pain: A review I. Topographic mappings. Pain, 1993, 54(2): 115-132.
 A. C. N. Chen. EEG/MEG brain mapping of human pain: Re- cent advances. International Congress Series, 2002, 1232: 5-16.
 S. D. Mayhew, H. W. Nicholas, C. Porcaro, et al. Intrinsic vari- ability in the human response to pain is assembled from multiple dynamic brain processes. Neuroimage, 2013, 75: 68-78.
 U. Pomper, M. Hofle, M. Hauck, et al. Crossmodal bias of visual input on pain perception and pain-induced beta activity. Neuro- image, 2013, 66: 469-478.
 M. Hofle, M. Hauck, A. K. Engel, et al. Viewing a needle prick- ing a hand that you perceive as yours enhances unpleasantness of pain. Pain, 2012, 153(5): 1074-1081.
 M. Hauck, J. Lorenz and A. K. Engel. Role of synchronized oscillatory brain activity for human pain perception. Reviews in the Neurosciences, 2008, 19(6): 441-450.
 I. Tracey. Nociceptive processing in the human brain. Current Opinion Neurobiology, 2005, 15(4): 478-87.
 J. Brooks, I. Tracey. From nociception to pain perception: Imag- ing the spinal and supraspinal pathways. Journal of Anatomy, 2005, 207(1): 19-33.
 J. Mo, M. Maizels, M. Z. Ding, et al. Does throbbing pain have a brain signature. Pain, 2013, 154(7): 1150-1155.
 S. Y. Shao, K. Q. Shen, K. Yu, et al. Frequency-domain EEG source analysis for acute tonic cold pain perception. Clinical Neurophysiology, 2012, 123(10): 2042-2049.
 R. R. Nir, A. Sinai, R. Moont, et al. Tonic pain and continuous EEG: Prediction of subjective pain perception by alpha-1 power during stimulation and at rest. Clinical Neurophysiology, 2012, 123(3): 605-612.
 S. Sauer, R. Schellenberg, H. C. Hofmann and W. Dimpfel. Functional imaging of headache-first steps in an objective quan- titative classification of migraine. European Journal of Medical Research, 1997, 2(9):367-376.
 W. Lutzenberger, H. Flor and N. Birbaumer. Enhanced dimen- sional complexity of the EEG during memory for personal pain in chronic pain patients. Neuroscience Letters, 1997, 226(3): 167-170.
 M. J. Russ, S. S. Campbell, T. Kakuma, et al. EEG theta activity and pain insensitivity in self-injurious borderline patients. Psy- chiatry Research, 1999, 89(3): 201-214.
 P.-F. Chang, L. Arendt-Nielsen. Psychophysical and EEG re- sponses to repeated experimental muscle pain in humans: Pain intensity encodes EEG activity. Brain Research Bulletin, 2003, 59(6): 533-543.
 B. Bromm, J. Lorenz. Neurophysiological evaluation of pain, Electroencephalography and Clinical Neurophysiology, 1998, 107(4): 227-253.
 E. Freye, J. V. Levy. The effects of tramadol on pain relief, fast EEG-power spectrum and cognitive function in elderly patients with chronic osteoarthritis (OA). Acute Pain, 2006, 8(2): 55-61.
 P.-F. Chang, L. Arendt-Nielsen and A. C. N. Chen. Differential cerebral responses to aversive auditory arousal versus muscle pain: Specific EEG patterns are associated with human pain pro- cessing. Experimental Brain Research, 2002, 147(3): 387-393.