Objective: To figure out the prevalence of hyperuricemia (HUA) and affected factors of the Zhuang residents in Fengshan County, and provide theoretical basis for the integrated control on HUA. Methods: 743 residents who are more than 20-year-old participated in this study in Fengshan County Bapang and Balie Village based on stratified random cluster sampling method by testing blood sugar, blood lipid, uric acid, and also with the questionnaire and physical examination. Results: The prevalence and standardized prevalence of HUA among Fengshan County Zhuang residents were 17.0% and 16.8% respectively. There were statistical significance on HUA prevalence among the Zhuang residents with difference between gender, age, obesity, diabetes mellitus, elevated blood uric acid, cholesterol, triglycerides, smoking, drink alcoholic, eating fat or animal internal organs, tea, vegetables, and physical exercise (P < 0.05 or P < 0.01), while the logistic analysis shows that hypertension, obesity, diabetes mellitus, smoking, drink alcoholic, eating fat or animal internal organs are the main factors. And the rates of risks are 4.4, 8.6, 3.9, 5.1 and 13.5 times respectively. Conclusion: The prevalence on HUA of Fengshan County Zhuang residents is high. And the significant risk factors for Fengshan County residents with HUA are the habits of smoking, eating fat and animal internal organs.