Vol.3 No.2 (April 2013)
The Function of PRGMC1 and Its Role in Tumorgenesis and Tumor Development
Progesterone receptor membrane component 1 (PGRMC1) is overexpressed in breast, colon, ovarian, lung and thyroid tumor tissues, as well as in cancer cell lines. PGRMC1 is associated with tumor growth and development, and it also can resist apoptosis of tumor cells, promote tumor growth independently and benefit to invasion and metas-tasis of tumor. PGRMC1 regulates cholesterol synthesis and signal transduction. Further studies on the relationship be-tween PGRMC1 and tumorigenesis will help to find new cancer biomarkers, which will provide theoretical and experi-mental evidences for early diagnosis and prognosis, as well as effective drug target for cancer.
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