Vol.3 No.1 (January 2013)
New Gene Therapy Vector—Nano-Hydroxyapatite
Hydroxyapatite (HAp) is the natural inorganic component of vertebrate bone and tooth tissues. It is currently one of the most important inorganic biological materials what can be synthesized by chemical regulation in large amounts. In recent years, owing to its good biocompatibility, excellent biodegradability and chemical synthesis of controllability, it received more and more attention in the application of hard tissue repair materials and drug controlled release vectors. This article reviews its transfection mechanism, biosecurity, controllability of chemical synthesis, biodegradability and targeting used as gene therapy vectors.
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