Vol.1 No.1 (July 2011)
Genome-Wide Survey, Identification and Preliminary Analysis of Xenopus Laevis Bhlh Transcription Factors
The basic helix-loop-helix (bHLH) transcription factors play essential roles in the regulation of eukaryotic growth and development and gene transcription. In this study, we conducted a genome-wide survey using the Xenopus Laevis ongoing genome project databases, and identified 98 bHLH sequences in Xenopus Laevis genome. Phylogenetic analyses revealed those bHLH genes belong to 32 families in the super-groups (A-F) in this research. Gene Ontology (GO) enrichment statistics showed 42 significant GO annotations counted in frequency. Statistical analysis of the Gene Ontology annotations showed that these 98 bHLH proteins tend to be related to transcription regulator activity (GO:0030528), regulation of transcription (GO:0045449), DNA binding (GO:0003677), transcription (GO:0006350), DNA-dependent regulation of transcription (GO:0006355）, expected from the common GO categories of transcriptional factors. A number of bHLH genes play regulation significant role in special development or physiology processes, such as muscle organ development and eye development. This preliminary study provides useful information for further researches on Xenopus Laevis.
刘武艺 (2011) 非洲爪蟾的碱性螺旋-环-螺旋转录因子的鉴定与初步分析。 生物医学， 1， 6-16. doi: 10.12677/hjbm.2011.11002
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