Vol.2 No.1 (March 2012)
Mutations in Mitochondrial DNA and Hypertension
Hypertension is one of the most common cardiovascular disease. It is one of the main risk factors associated with cardiovascular death. Mutations in mitochondrial DNA lead to failures in metabolism, affecting mitochondrial protein synthesis and oxidative phosphorylation function. These mutations result in a deficit in ATP synthesis and an increase of generation of reactive oxygen species. As a result, mitochondrial DNA mutation has been the highlight in this filed. These findings will be helpful for understanding the molecular mechanism of maternally inherited hypertension. It may provide new insights into management and treatment of maternally inherited hypertension. This review summarized the association between mtDNA mutations and hypertension.
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