计算生物学

Vol.1 No.2 (December 2011)

癌症差异表达基因的似然比–置换检验法
Likelihood Ratio-Permutation Test of Differentially Expressed Cancer-Related Genes

 

作者:

李靖喆 , 张帼奋

 

关键词:

DNA微阵列(基因芯片)基因选择似然比检验置换检验DNA Microarray (Gene Chips) Gene Selection Likelihood Ratio Test Permutation Test

 

摘要:

癌症的差异表达基因具有其特殊性,这种特殊性给基因选择带来了新的挑战。许多统计学家提出了新的统计量和检验方法,不断地在这一领域取得突破和完善。本文将在借鉴这些已有研究成果的基础上,运用统计学中两种经典的常用方法,提出一种有效的手段——似然比–置换检验法,用以甄选癌症的差异表达基因。

The particularity of the differentially expressed cancer-related genes brings new challenges in the field of gene selection. Statisticians have succeeded in proposing new statistics and methods to solve the problem of selecting differentially expressed cancer gene. This article will advance a new method called “Likelihood Ratio-Permutation Test”, in order to select differentially expressed genes under the cancer model, after referencing some existing research.

文章引用:

李靖喆 , 张帼奋 (2011) 癌症差异表达基因的似然比–置换检验法。 计算生物学, 1, 22-26. doi: 10.12677/hjcb.2011.12004

 

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