计算生物学

Vol.1 No.1 (September 2011)

基于序列关联的蛋白质亚细胞定位识别
Recognition of Subcellular Localization of Proteins Using of Sequences Fusion

 

作者:

贾芸

 

关键词:

亚细胞定位F值二次判别分析Subcellular Localization F-Value Quadratic Discriminant Analysis

 

摘要:

对未知蛋白的功能注释是蛋白质组学的主要目标。一个关键的注释是蛋白质亚细胞定位的预测。应用基于序列关联的二次判别分析方法进行蛋白质亚细胞定位预测,对4个植物定位类型进行5-fold交叉检验。

Functional annotation of unknown proteins is a major goal in proteomics. A key annotation is the prediction of a protein’s subcellular localization. We used the method of Increment of Diversity with Quad-ratic Discriminant analysis (IDQD) to predict subcellular localization of proteins which are recognized by the four plant categories and three non-plant and obtained accuracy 87.4(±0.5)% and 91.2(±0.2)%, respectively in 5-fold cross-validation test. Our result is better than comparable existing methods.

文章引用:

贾芸 (2011) 基于序列关联的蛋白质亚细胞定位识别。 计算生物学, 1, 1-3. doi: 10.12677/hjcb.2011.11001

 

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