Vol.6 No.4 (November 2016)
Quick Determination of Antibiotics Residues in Water Samples by Magnetic Multiwalled Carbon Nanotubes Cleaning Technology
A method was established for determining 23 antibiotics residues in water samples by magnetic multiwalled carbon nanotubes and ultra performance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS). The 23 antibiotics in water samples were first enriched and cleaned up by magnetic multiwalled carbon nanotubes, and then eluted with ammonium hy-droxide-methanol (5:95, v/v). The target antibiotics were separated by Waters CORTECSTM C18+ column using methanol and 0.1% formate in water as mobile phases. The analytes were detected by positive electrospray ionization with multiple reaction monitoring. External standard method was used to determine the quantity. In the linear range of 0.5~50 μg/L, the correlation coefficients of 23 antibiotics were greater than 0.99, the limit of detection (LOD) was 0.01 μg/L, and the limit of quantitation (LOQ) was 0.03 μg/L. The mean recoveries at the three spiked levels of 0.05, 0.5, 10 μg/L were 87.5%~105.8%. The relative standard deviation (RSD) was 0.3%~4.2%. The simplicity, sensitivity and good precision of the method made it be well suitable for quick determination of the 23 antibiotics residues in water samples.
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