Vol.6 No.4 (December 2016)
Langerhans Cell Histiocytosis in Lymph Nodes: A Case Report and Review of the Literature
Langerhans cell histiocytosis (LCH) is a neoplastic diseases majorly formed by the clonal neoplastic proliferation of Langerhans cells, and single-system which occurs in the lymph nodes is rare. So the clinical misdiagnosis often occurs. In this case, a 45-year-old man was admitted to hospital with a history of fever and a right groin mass for more than one month. Under microscopy, the structure of the lymph node was almost damaged, which was caused by the idiopathic proliferation of Langerhans cell and eosinophils or eosinophilic abscess. The Langerhans cells ranged from medium to relatively large in size and the cytoplasm is rich and eosinophilic. The nuclear was round, oval, bean-like or irregular in shape, showing clear grooves and depressions. Immunohistochemical study showed that the Langerhans cells were strongly positive for S-100 protein, CD1a, CD68, vimentin, and negative for HMB45, CD21, CD45, CD20, CD3, CK, CD30, EMA. The patient was recovered well after surgery.
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