Vol.4 No.1 (February 2015)
The Study on the Synthesis of PGs Ke Intermediate—Corey Lactone
Corey lactone is the key intermediate of synthetizing the prostaglandin analogues. In this paper, we use the norbornadiene as the raw material to synthetize the Corey lactone. Through Prins reaction, Baeyer-Villiger oxidation, splitting the chiral intermediate and a series of reaction successfully, the structure has been confirmed by the LC-MS and the NMR. The reagent and the solvent which are used in this method are so common and inexpensive that they can be suitable for industrialized production.
邓 涛 , 毛 伟 , 陶 春 , 李勤耕 (2015) 前列腺素类药物关键中间体Corey Lactone的合成工艺研究。 药物资讯， 4， 15-21. doi: 10.12677/PI.2015.41002
 Cheung, C.Y., Beardall, M.K., Anderson, D.F. and Brace, R.A. (2014) Prostaglandin E2 regulation of amnion cell vascular endothelial growth factor expression: relationship with intramembranous absorption rate in fetal sheep. Brace American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, 307, 354-360.
 Maddipati, K.R., Romero, R., Chaiworapongsa, T., Zhou, S.L., Xu, Z., Tarca, A.L., Kusanovic, J.P., Munoz, H. and Honn, K.V. (2014) Eicosanomic profiling reveals dominance of the epoxygenase pathway in human amniotic fluid at term in spon-taneous labor. The FASEB Journal, 28, 4835-4846.
 Noonan, J.E., Dusting, G.J., Nguyen, T.T., Jenkins, A., Man, R.E., Best, W.J., Dias, D.A., Jayasinghe, N.S., Roessner, U. and Lamoureux, E.L. (2014) Flicker light-induced retinal vasodilation is unaffected by inhibition of epoxyeicosatrienoic acids and prostaglandins in humans. Investigative Oph-thalmology & Visual Science, 55, 7007-7013.
 Shewchuk, B.M. (2014) Prostaglandins and n-3 polyunsaturated fatty acids in the regulation of the hypothalamic-pi- tuitary axis. Prostaglandins, Leukotrienes and Essential Fatty Acids, 91, 277-287.
 Kim, S.F. (2014) The nitric oxide-mediated regulation of prostaglandin signaling in medicine. Vitamins & Hormones, 96, 211-245.
 Banks, W.A. (2014) The blood-brain barrier in neuroimmunology: Tales of separation and assimilation. Brain, Behavior, and Immunity, 44C, 1-8.
 Corey, E.J., Weinshenker, N.M. and Schaaf, T.K. (1969) Willy Huber. Stereo-controlled synthesis of prostaglandins F2α and E2 (dl). Journal of the American Chemical Society, 91, 5675-5677.
 Corey, E.J., Albonico, S.M., Koelliker, U., et al. (1971) New reagents for stereoselective carbonyl reduction. An im- proved synthetic route to primany prostaglandins. Journal of the American Chemical Society, 93, 1491-1493.
 Bindra, J.S., Grodski, A., Schaaf, T.K., et al. (1973) New extensions of the bicyclo [2.2.1] heptane route to prostaglan- dins. Journal of the American Chemical Society, 95, 7522-7523.
 Corey (1971) Novel prostaglandin intermediates. US3992438, 180, 24.
 龚彦春, 徐红, 谢涓等 (2012) Corey内酯中间体2-氧代三环 [184.108.40.206](3,5)] 庚烷-7-羧酸的新拆分方法. 中国药科大学学报, 5, 385-389.