Vol.3 No.4 (November 2014)
The Synthesis Research of Vitamin E Acetate
Synthetic vitamin E is mainly used as feed additives; the development speed of China’s feed indus-try is very fast, and the annual growth rate is around 20%, which has broad market prospects. In this process, 2,3,6-trimethylphenol, used as raw material, is oxidated to 2,3,5-trimethyl benzo-quinone by air, and reduced to 2,3,5-trimethyl hydroquinone by H2; the product TMHQ is concen-trated with isophytol to generate vitamin E, which is then acylated to get the vitamin E acetate with an overall yield of 86.4%. The target compound and key intermediates are confirmed by NMR and MS. The improved synthesis is benefited from simple equipment, mild conditions, and high yield, with large-scale production potential.
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