Vol.4 No.4 (December 2014)
Progress in Mechanisms of Contrast-Induced Nephropathy
Contrast-induced nephropathy (CIN), one of the most severe complications after using contrast agent, is a common reason of acute renal insufficiency which occurs in hospital and a severe threat to human health. Common risk factors of CIN include chronic renal insufficiency, diabetes, age and else. The mechanisms of CIN are complex, including the change of haemodynamics of renal, direct renal toxicity of contrast agent, obstruction of kidney tubules and immunological factors. The changes of renal hemodynamic and direct renal toxicity of contrast agent are critical factors in the development of CIN. Studies on risk factors and mechanism of CIN provide theoretical basis for the prevention and treatment of CIN, indicate new direction, and help to reduce adverse effects after using contrast agent for diagnosis and treatment. The current paper is to review the most recent development.
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