Vol.4 No.1 (January 2014)
Pathway Analysis Suggest the Calcium Signaling Pathway Associated with Alcohol Dependence
Background: Alcohol dependence (AD) is a serious and common public health problem. A large number of association studies were conducted to identify susceptibility genes of AD, but efforts to generate an integrate view of accumulative genetic variants and pathways under alcohol drinking are lacking. Methods: We applied enrichment gene set analysis to existing genetic association results to identify pertinent pathways to alcohol dependence in this study. A total of 1438 SNPs (P < 1.0 ´ 10−3) associated to alcohol drinking related-traits have been collected from 31 studies. Results: The calcium signaling pathway (hsa04020) showed the most significant enrichment of associations (21 genes) to alcohol consumption phenotypes (P = 5.4 ´ 10−5), achieving bonferroni P value of 0.8 ´ 10−3 and FDR value of 0.6 ´ 10−2, respectively. Interestingly, the calcium signaling pathway was previously found to be essential to regulate brain function. Genes in this pathway link to a depressive effect of alcohol consumption on the body. Conclusions: Our findings, together with previous biological evidence suggest the importance of gene polymorphisms of calcium signaling pathway to alcohol dependence susceptibility.
郭艳芳 (2014) 通路分析提示钙信号转导通路与酒精依赖关联。 生物医学， 4， 1-6. doi: 10.12677/HJBM.2014.41001
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