Vol.3 No.3 (May 2013)
Preparation of PGlu/PPy Composite Nanoparticles and Neurotoxicity Evaluation
Polypyrrole (PPy) nanoparticles doped with poly(glutamic acid) (PGlu) or PGlu/sodium dodecyl sulfate (SDS) were prepared by oxidation polymerization. The PPy nanoparticles were characterized via standard four-probe setup, FT-IR, SEM, Laser Particle Size Analyzer (LPSA) and zeta CAD. In order to evaluate the cytotoxicity and neurotoxicity, the PPy particles were co-cultured with L929 and PC12, respectively. The results show that the dopants have an effect on the morphology and conductivity of PPy nanoparticles. PGlu doped PPy nanoparticles have good cell compatibility. The addition of SDS is beneficial to improve the conductivity of PPy nanoparticles, however it is slightly to the disadvantage of cell viability and neuron growth.
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